Hormonal Disturbances in Women with Premature Ovarian Insufficiency

Abstract

Background: 3.7% of women before the age of 40 have premature ovarian insufficiency (POI), which is characterized by the loss of ovarian activity and is still a common cause of infertility in women [1]. Objective: Measuring Body Mass Index (BMI) and concentrations of some parameters (Anti Mullerian Hormone (AMH), Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), testosterone, and Estradiol (E2) in serum of POI patients. Materials and Procedures: A case-control study involving 100 women (50 POI patients and 50 healthy control). BMI, AMH, Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), testosterone, and Estradiol (E2) were measured using an enzyme-linked immunosorbent assay and chemiluminescent automated immunoassay system (ECL) (Cobas e 411). Results: The study's findings demonstrated There were statistically significant differences in the mean BMI values between the POI patients and the control group, The results also showed a significant increase in levels of FSH and LH, and significant decrease in levels of AMH, testosterone, and Estradiol (E2) in POI women in comparison with healthy women. Conclusion: The BMI group between (25-29.5 kg/m²) is the most category predispose to have Premature Ovarian Insufficiency (POI) among the BMI groups in the study. Increase in levels of FSH and LH, and decrease in levels of AMH, testosterone, and Estradiol (E2) can act as an indicators in POI-affected women.